Autonomic cardiovascular responses in parkinsonism: effect of levodopa with dopa‐decarboxylase inhibition
Identifieur interne : 000292 ( Main/Corpus ); précédent : 000291; suivant : 000293Autonomic cardiovascular responses in parkinsonism: effect of levodopa with dopa‐decarboxylase inhibition
Auteurs : Charlotte Sachs ; Bo Berglund ; Lennart KaijserSource :
- Acta Neurologica Scandinavica [ 0001-6314 ] ; 1985-01.
English descriptors
Abstract
ABSTRACT – Autonomically mediated cardiovascular responses to certain manoeuvres were studied in 20 parkinson patients, 24 h off levodopa‐decarboxylase inhibitor medication and again one h after medication. Results were compared with 15 healthy control subjects. The heart rate at rest was higher in parkinson, the respiratory sinus arrhythmia was lower, while the Valsalva ratio, the heart rate and blood pressure responses during an orthostatic test and the heart rate response to a dive reflex test were normal. These findings indicate a normal function of peripheral autonomic nerves and a possible central parasympathetic dysfunction. There were significantly attenuated responses of heart rate, blood pressure and contralateral forearm blood flow to an isometric handgrip. Since the peripheral autonomic nerves seemed to be normal, these results could be related to a reduced central command and/or diminished stimulation of postulated peripheral ergoreceptors in parkinsonism. There was no major effect on the cardiovascular responses by the acutely administered medication.
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DOI: 10.1111/j.1600-0404.1985.tb03164.x
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Results were compared with 15 healthy control subjects. The heart rate at rest was higher in parkinson, the respiratory sinus arrhythmia was lower, while the Valsalva ratio, the heart rate and blood pressure responses during an orthostatic test and the heart rate response to a dive reflex test were normal. These findings indicate a normal function of peripheral autonomic nerves and a possible central parasympathetic dysfunction. There were significantly attenuated responses of heart rate, blood pressure and contralateral forearm blood flow to an isometric handgrip. Since the peripheral autonomic nerves seemed to be normal, these results could be related to a reduced central command and/or diminished stimulation of postulated peripheral ergoreceptors in parkinsonism. There was no major effect on the cardiovascular responses by the acutely administered medication.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Charlotte Sachs</name><affiliations><json:string>Department of Neurology, Karolinska Hospital, Stockholm, Sweden</json:string></affiliations></json:item><json:item><name>Bo Berglund</name><affiliations><json:string>Department of Clinical Physiology, Karolinska Hospital, Stockholm, Sweden</json:string></affiliations></json:item><json:item><name>Lennart Kaijser</name><affiliations><json:string>Department of Clinical Physiology, Karolinska Hospital, Stockholm, Sweden</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Autonomic nervous system</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>parkinsonism</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>respiratory sinus arrhythmia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Valsalva manoeuvre</value></json:item></subject><articleId><json:string>ANE37</json:string></articleId><language><json:string>eng</json:string></language><abstract>ABSTRACT – Autonomically mediated cardiovascular responses to certain manoeuvres were studied in 20 parkinson patients, 24 h off levodopa‐decarboxylase inhibitor medication and again one h after medication. 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Results were compared with 15 healthy control subjects. The heart rate at rest was higher in parkinson, the respiratory sinus arrhythmia was lower, while the Valsalva ratio, the heart rate and blood pressure responses during an orthostatic test and the heart rate response to a dive reflex test were normal. These findings indicate a normal function of peripheral autonomic nerves and a possible central parasympathetic dysfunction.</p><p>There were significantly attenuated responses of heart rate, blood pressure and contralateral forearm blood flow to an isometric handgrip. Since the peripheral autonomic nerves seemed to be normal, these results could be related to a reduced central command and/or diminished stimulation of postulated peripheral ergoreceptors in parkinsonism.</p><p>There was no major effect on the cardiovascular responses by the acutely administered medication.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Autonomic cardiovascular responses in parkinsonism: effect of levodopa with dopa‐decarboxylase inhibition</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Autonomic cardiovascular responses in parkinsonism: effect of levodopa with dopa‐decarboxylase inhibition</title></titleInfo><name type="personal"><namePart type="given">Charlotte</namePart><namePart type="family">Sachs</namePart><affiliation>Department of Neurology, Karolinska Hospital, Stockholm, Sweden</affiliation><description>Correspondence: Department of Neurology Karolinska Sjukhuset S‐10401 Stockholm Sweden</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bo</namePart><namePart type="family">Berglund</namePart><affiliation>Department of Clinical Physiology, Karolinska Hospital, Stockholm, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lennart</namePart><namePart type="family">Kaijser</namePart><affiliation>Department of Clinical Physiology, Karolinska Hospital, Stockholm, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1985-01</dateIssued><edition>Accepted for publication July 4, 1984</edition><copyrightDate encoding="w3cdtf">1985</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">31</extent></physicalDescription><abstract lang="en">ABSTRACT – Autonomically mediated cardiovascular responses to certain manoeuvres were studied in 20 parkinson patients, 24 h off levodopa‐decarboxylase inhibitor medication and again one h after medication. Results were compared with 15 healthy control subjects. The heart rate at rest was higher in parkinson, the respiratory sinus arrhythmia was lower, while the Valsalva ratio, the heart rate and blood pressure responses during an orthostatic test and the heart rate response to a dive reflex test were normal. These findings indicate a normal function of peripheral autonomic nerves and a possible central parasympathetic dysfunction. There were significantly attenuated responses of heart rate, blood pressure and contralateral forearm blood flow to an isometric handgrip. Since the peripheral autonomic nerves seemed to be normal, these results could be related to a reduced central command and/or diminished stimulation of postulated peripheral ergoreceptors in parkinsonism. There was no major effect on the cardiovascular responses by the acutely administered medication.</abstract><subject lang="en"><genre>Keywords</genre><topic>Autonomic nervous system</topic><topic>parkinsonism</topic><topic>respiratory sinus arrhythmia</topic><topic>Valsalva manoeuvre</topic></subject><relatedItem type="host"><titleInfo><title>Acta Neurologica Scandinavica</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0001-6314</identifier><identifier type="eISSN">1600-0404</identifier><identifier type="DOI">10.1111/(ISSN)1600-0404</identifier><identifier type="PublisherID">ANE</identifier><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>71</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>37</start><end>42</end><total>6</total></extent></part></relatedItem><identifier type="istex">2EAA5FA75F93E81A7FDF256747DD97A13CFC83FA</identifier><identifier type="DOI">10.1111/j.1600-0404.1985.tb03164.x</identifier><identifier type="ArticleID">ANE37</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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